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Yeast and/or fluoxetine prevent UCMS-induced <t>CREB</t> and MAPK activities dysregulation in mice. Bars represent the mean ± S.E.M. ∗ p < 0.0001 compared to normal control group, # p < 0.0001 compared to negative control group and β p < 0.05 compared to fluoxetine (20 mg/kg) group. VEH = vehicle; FLX = fluoxetine; CREB = cAMP response element-binding protein; MAPK = mitogen-activated protein kinase; UCMS = unpredictable chronic mild stress.
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Yeast and/or fluoxetine prevent UCMS-induced <t>CREB</t> and MAPK activities dysregulation in mice. Bars represent the mean ± S.E.M. ∗ p < 0.0001 compared to normal control group, # p < 0.0001 compared to negative control group and β p < 0.05 compared to fluoxetine (20 mg/kg) group. VEH = vehicle; FLX = fluoxetine; CREB = cAMP response element-binding protein; MAPK = mitogen-activated protein kinase; UCMS = unpredictable chronic mild stress.
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Yeast and/or fluoxetine prevent UCMS-induced <t>CREB</t> and MAPK activities dysregulation in mice. Bars represent the mean ± S.E.M. ∗ p < 0.0001 compared to normal control group, # p < 0.0001 compared to negative control group and β p < 0.05 compared to fluoxetine (20 mg/kg) group. VEH = vehicle; FLX = fluoxetine; CREB = cAMP response element-binding protein; MAPK = mitogen-activated protein kinase; UCMS = unpredictable chronic mild stress.
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Yeast and/or fluoxetine prevent UCMS-induced <t>CREB</t> and MAPK activities dysregulation in mice. Bars represent the mean ± S.E.M. ∗ p < 0.0001 compared to normal control group, # p < 0.0001 compared to negative control group and β p < 0.05 compared to fluoxetine (20 mg/kg) group. VEH = vehicle; FLX = fluoxetine; CREB = cAMP response element-binding protein; MAPK = mitogen-activated protein kinase; UCMS = unpredictable chronic mild stress.
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Yeast and/or fluoxetine prevent UCMS-induced CREB and MAPK activities dysregulation in mice. Bars represent the mean ± S.E.M. ∗ p < 0.0001 compared to normal control group, # p < 0.0001 compared to negative control group and β p < 0.05 compared to fluoxetine (20 mg/kg) group. VEH = vehicle; FLX = fluoxetine; CREB = cAMP response element-binding protein; MAPK = mitogen-activated protein kinase; UCMS = unpredictable chronic mild stress.

Journal: Current Research in Physiology

Article Title: Yeast supplementation potentiates fluoxetine's anti-depressant effect in mice via modulation of oxido-inflammatory, CREB, and MAPK signaling pathways

doi: 10.1016/j.crphys.2024.100132

Figure Lengend Snippet: Yeast and/or fluoxetine prevent UCMS-induced CREB and MAPK activities dysregulation in mice. Bars represent the mean ± S.E.M. ∗ p < 0.0001 compared to normal control group, # p < 0.0001 compared to negative control group and β p < 0.05 compared to fluoxetine (20 mg/kg) group. VEH = vehicle; FLX = fluoxetine; CREB = cAMP response element-binding protein; MAPK = mitogen-activated protein kinase; UCMS = unpredictable chronic mild stress.

Article Snippet: The following agents were obtained from various sources: fluoxetine capsules (Fidson Healthcare PLC, Lagos, Nigeria), nutritional yeast (Kunimed Pharmachem Limited, Lagos, Nigeria), lipopolysaccharide (LPS; E. coli, serotype 055:B5) (Sigma-Aldrich, St. Louis, USA), ELISA kits for TNF-α and IL-6 (Bio Legend, USA), CREB and MAPK ELISA kits (Wuhan Fine Biotech Co., Ltd, China), and corticosterone ELISA kit (Oxford Biomedical Research, USA).

Techniques: Control, Negative Control, Binding Assay

Yeast and/or fluoxetine prevent UCMS-induced CREB and MAPK activities dysregulation in mice. Bars represent the mean ± S.E.M. ∗ p < 0.0001 compared to normal control group, # p < 0.0001 compared to negative control group and β p < 0.05 compared to fluoxetine (20 mg/kg) group. VEH = vehicle; FLX = fluoxetine; CREB = cAMP response element-binding protein; MAPK = mitogen-activated protein kinase; UCMS = unpredictable chronic mild stress.

Journal: Current Research in Physiology

Article Title: Yeast supplementation potentiates fluoxetine's anti-depressant effect in mice via modulation of oxido-inflammatory, CREB, and MAPK signaling pathways

doi: 10.1016/j.crphys.2024.100132

Figure Lengend Snippet: Yeast and/or fluoxetine prevent UCMS-induced CREB and MAPK activities dysregulation in mice. Bars represent the mean ± S.E.M. ∗ p < 0.0001 compared to normal control group, # p < 0.0001 compared to negative control group and β p < 0.05 compared to fluoxetine (20 mg/kg) group. VEH = vehicle; FLX = fluoxetine; CREB = cAMP response element-binding protein; MAPK = mitogen-activated protein kinase; UCMS = unpredictable chronic mild stress.

Article Snippet: CREB levels were measured using a CREB ELISA kit (Wuhan Fine Biotech Co., Ltd, China).

Techniques: Control, Negative Control, Binding Assay